Dr. Rai,Beena

Principal Scientist, TCS Innovation Labs – Pune (TRDDC), Process Engineering

Dr. Beena Rai secured her Ph. D. (Chemistry) from National Chemical Laboratory (University of Pune)  in 1995.

Areas of Research Interests:

  • Computational Chemistry and Molecular Modeling: Applications in minerals and metals industry, design of industrial performance chemicals and biologically active molecules, modeling of polymers and proteins, modeling of interfaces, prediction of surface tension, wettability of surfaces, prediction of contact angle, design of drug and cosmetics formulations 
  • Synthetic Organic Chemistry: Application in pharmaceuticals, agrochemicals and surfactants/additives/polymers for industrial applications
  • Waste Recycling/Reclamation: Eco-cements from mineral and metallurgical wastes, elemental sulfur from chemical sludge
  • Nano-bio Technology: Drug delivery through polymers, adsorption of proteins, development of biosensors, synthesis and processing of nanoparticles, nanofluids for heat transfer applications
  • Functional Coatings: Low friction coatings for medical devices, chemically resistant coatings for fabrics, scratch resistance coatings

List of Publications(395 KB)

Awards & Honors

  • Efficiency of blocking of nonspecific interaction of different proteins by BSA adsorbed on hydrophobic and hydrophilic surfaces”, Journal of Colloid and Interface Science”, 341 (2010) 136–142. (2010 – 2011). 
    Top Cited Article
    Authors: Jeyachandran Y. L., Mielczarski, J. A. Mielczarski E. and Rai B., Abstract:

    The efficiency of a pre-absorbed bovine serum albumin (BSA) layer in blocking the non-specific adsorption of different proteins on hydrophobic and hydrophilic surfaces was evaluated qualitatively and quantitatively using infrared reflection spectroscopy supported by spectral simulations. A BSA layer with a surface coverage of 35% of a close-packed monolayer exhibited a blocking efficiency of 90–100% on a hydrophobic and 68–100% on a hydrophilic surface, with respect to the non-specific adsorption of concanavalin A (Con A), immunoglobulin G (IgG), and staphylococcal protein A (SpA). This BSA layer was produced using a solution concentration of 1 mg/mL and 30 min incubation time. BSA layers that were adsorbed at conditions commonly employed for blocking (a 12 h incubation time and a solution concentration of 10 mg/mL) exhibited a blocking activity that involved competitive adsorption–desorption. This activity resulted from the formation of BSA–phosphate surface complexes, which correlated with the conformation of adsorbed BSA molecules that was favourable for blocking. The importance of optimisation of the adsorbed BSA layer for different surfaces and proteins to achieve efficient blocking was addressed in this study.

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