As counterfeiting of drugs is increasing, the pharmaceutical industry and regulatory agencies are adopting multiple anti-counterfeit strategies such as new regulations, secure drug supply chain and widen awareness about counterfeiting of drugs among stakeholders. One of such strategy is to have secured supply chain – which require – which requires ability to trace, validate and verify the authenticity of the drug at any stage of the supply chain (e-pedigree regulation).

This paper highlights the drug counterfeit challenges and discusses the approaches to handle “serialization” through track and trace of drug in supply chain. It provides approach to deploy mass serialization using EPC and carrier technologies like 2D-barcodes and Radio Frequency Identification (RFID). And also provides option to implement solution to meet the ePedigree requirement leveraging industry standards such as EPCIS and DPMS.