Technology played a crucial role during the COVID-19 pandemic in ensuring smooth operations of clinical trials. The overhaul in the operations conducted on a digital platform in a unique phygital mode offered various advantages. It enabled shifting focus from site-centricity to patient centricity. Though overall timelines have been impacted through multiple protocol amendments as new design operation enablers, it has identified alternative approaches to aid virtual operations that are compliant with regulatory requirements. The whitepaper sheds light on how diverse technologies can be streamlined to improve clinical operations and identify and resolve the unmet needs of patients.