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A scientist wearing a face mask works on genetic research inside a lab.

RESEARCH AREA

Life Sciences

Reading genomes to tell the future.

 

Overview

The core focus of the life sciences research area team is computational genomics. This involves researching and designing solutions that employ a combination of artificial intelligence, cognitive computing capabilities, robotic process automation, the internet of things, and cloud computing to fully digitize the life sciences value chain.

Fields

The team works across the following areas of research:

  • Human genome variation interpretation: This research group uses genome variation analysis to identify the genetic causes of rare disorders in order to design appropriate diagnostics and cures. They are also exploring next-generation sequencing as a tool to replace screening tests. Another area of research is the construction and use of genotype-phenotype-disease networks using natural language processing to identify novel gene-disease relationships

  • Pan-genome analysis: This team works on developing efficient algorithms to represent a collection of genomes as a graph (pan-genome), and then uses these graphs to identify specific strains of microbes in human genomes

  • Metagenomics and systems biology: This group specializes in identifying microbiome-based biomarkers that have clinical application or utility in the early detection or diagnosis of asymptomatic diseases and metabolic or genetic disorders. Modeling and simulation of biological systems that affect different hierarchies of life is also another area of interest

  • Computational structural biology: This team is working on using multi-scale molecular modeling simulations and analysis of biological networks to identify new drug targets for infectious diseases

  • Model-informed drug discovery and development: This group is developing tools that incorporate accurate models for estimating the viability of candidate drug molecules and to discard unviable molecules as early as possible in the drug discovery and development process

People & Patents

  • Research team: Led by Chief Scientist Rajgopal Srinivasan, Naveen Sivadasan, Sharmila Mande, and B Gopalakrishnan, the team includes researchers Akriti Jain; Poulami Chaudhuri; Sadhna Rana; Sutapa Datta; Uma Sunderam; Aditya Rao; V. G. Saipradeep; Thomas Joseph; Kavya Vaddadi; Vidushi Walia; Mohammed Monzoorul Haque; Anirban Dutta; Swadha Anand; Kuntal Kumar Bhusan; Chandrani Das; Tungadri Bose; Nishal Kumar Pinna; Sunil Nagpal; Deepak Yadav; Mitali Merchant; Venkata Siva Kumar Reddy Chennareddy; Harrisham Kaur; Rashmi Singh; Vineet Bhatt; Anwesha Mohapatra; Subhrajit Bhar; Arvind Shankar; Krishanu Das Baksi; Preethi Sampath; Arijit Roy; Siladithya Padhi; Navneet Bung; and Dibyajyoti Das

  • Academic partners: University of California at Berkeley, USA; Mount Sinai School of Medicine, USA; National Institute of Occupational Health and Safety, USA; Tata Medical Center, India; Dr. Reddy’s Institute of Life Sciences, India; IIIT Hyderabad, India; AIIMS, India; ICGEB, India; NCCS, India; IISc, India; CDFD, India; Bose Institute, India; IISER, India; IIT Bombay, India; IIT Kharagpur, India; MDRF, India; NCL, India; NII, India; THSTI, India; University of Hyderabad, India; University of Copenhagen, Denmark

  • Patents and publications (FY18 onwards): This research area team has received three patents and has had its work published in over 30 conferences, workshops, and journals

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