The core focus of the life sciences research area team is computational genomics. This involves researching and designing solutions that employ a combination of artificial intelligence, cognitive computing capabilities, robotic process automation, the internet of things, and cloud computing to fully digitize the life sciences value chain.
The team works across the following areas of research:
Human genome variation interpretation: This research group uses genome variation analysis to identify the genetic causes of rare disorders in order to design appropriate diagnostics and cures. They are also exploring next-generation sequencing as a tool to replace screening tests. Another area of research is the construction and use of genotype-phenotype-disease networks using natural language processing to identify novel gene-disease relationships
The group is led by Dr. Rajgopal Srinivasan and includes Akriti Jain, Poulami Chaudhuri, Sadhna Rana, Sutapa Datta, Uma Sunderam, Aditya Rao, V G Saipradeep, Naveen Sivadasan & Thomas Joseph
Academic Partners: University of California at Berkeley, Tata Medical Center Kolkata
Pan-genome analysis: This team works on developing efficient algorithms to represent a collection of genomes as a graph (pan-genome), and then uses these graphs to identify specific strains of microbes in microbial communities
The group is Led by Dr. Naveen Sivadasan, and includes Kavya Vaddadi, Vidushi Walia
Metagenomics and systems biology: This group specializes in identifying microbiome-based biomarkers that have clinical application or utility in the early detection or diagnosis of asymptomatic diseases and metabolic or genetic disorders. Modeling and simulation of biological systems that affect different hierarchies of life is also another area of interest
The group is led by Dr. Sharmila Mande and includes Mohammed Monzoorul Haque, Anirban Dutta, Swadha Anand, Kuntal Kumar Bhusan, Chandrani Das, Tungadri Bose, Nishal Kumar Pinna, Sunil Nagpal, Deepak Yadav, Mitali Merchant, Venkata Siva Kumar Reddy Chennareddy, Harrisham Kaur, Rashmi Singh, Vineet Bhatt, Anwesha Mohapatra, Subhrajit Bhar, Arvind Shankar, Krishanu Das Baksi, Preethi Sampath
Academic Partners: AIIMS, New Delhi; ICGEB, New Delhi; NCCS, Pune; IISc, Bangalore; CDFD, Hyderabad; Bose Institute, Kolkata; IISER, Mohali; IIT Bombay; IIT Kharagpur; MDRF, Chennai; NCL, Pune; NII, New Delhi; THSTI, Gurgaon; University of Hyderabad; University of Copenhagen
- Computational structural biology: This team is working on:
- Using multi-scale modelling and simulation to obtain fundamental insights into the structural dynamics of biomolecules (especially drug targets)
- Applying deep learning and other AI-based methods for drug discovery
- Using network-based methods for drug target identification and drug repurposing.
The team is led by Dr. B. Gopalakrishnan, and includes Dr. Arijit Roy, Dr. Siladitya Padhi, Dr. Navneet Bung, Dr. Broto Chakrabarty, Dibyajyoti Das, and Sowmya Ramaswamy Krishnan.
Academic Collaborations: University of Oxford, Oxford, UK; Icahn School of Medicine, New York, USA; National Institute of Occupational Health and Safety, Morgantown, USA; Dr. Reddy’s Institute of Life Sciences, Hyderabad, India; International Institute of Information Technology, Hyderabad, India; University of Hyderabad, Hyderabad, India
Model-informed drug discovery and development: This group is developing tools that incorporate accurate models for estimating the viability of candidate drug molecules and to discard unviable molecules as early as possible in the drug discovery and development process
The Group is headed by Dr Rajgopal Srinivasan (Chief Scientist, Ph D, Genome Interpretation)
Patents & Publications
Patents and publications (2016 onwards): This research area team has received three patents and has had its work published in over 30 conferences, workshops, and journals