A transmural anisotropic ventricular tissue model consists of endocardial, mid myocardial, and epicardial myocytes which are configured to investigate drug interaction, such as Hydroxychloroquine (HCQ), under hypoxia conditions without and with pro-arrhythmic comorbidity. In ventricular model, HCQ has a trivial effect on hypoxia, except in the combination of mild hypoxia with moderate hypokalemia and severe hypoxia with mild hypokalemia, where it initiates reentrant arrhythmia. Secondly, incorporating drug dosage variations indicates 10 μM HCQ for all settings except in severe hypoxia conditions where reentrant arrhythmia occurred. The protocol influences the appearance of reentrant arrhythmia for severe hypoxia with 10 μM HCQ dosage. For other conditions, including tachycardiac pacing protocol, no arrhythmia occurred. These findings infer that arrhythmic fatality rate can be alleviated by altering the dosage of HCQ and aid in the treatment of hypoxia-induced symptoms caused by COVID.
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