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    TCS is here to make a difference through technology.

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      15 May 2025 TCS Recognized as One of the World’s Top 50 Brands by Kantar BrandZ; Brand Value Soars 28% YoY to $57.3Bn
      14 May 2025 TCS Partners with Khan Bank to Future-Proof its Operations, Enhance Customer Experience and Propel Innovation leveraging AI and ML
      12 May 2025 TCS Partners with Dhofar Insurance Company to Transform its Core Insurance Platform
      View all
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      02 May 2025 TCS Ranked Denmark’s #1 IT Service Provider for Customer Satisfaction in 2025
      23 Apr 2025 TCS Partners with Google Cloud on Agent-to-Agent Interoperability Protocol to Drive Future-Ready Enterprises
      11 Apr 2025 TCS Partners with Google Cloud to Accelerate AI-led Transformation in the Retail Sector
      View all
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      Recent recognitions

      22 Apr 2025 TCS Ranked #6 Amongst Banking Technology Providers and Recognized as a Regional Leader across all Geographies by Everest Group
      17 Apr 2025 TCS BaNCS Named a Leader Among Wealth Management Products by Everest Group
      01 Apr 2025 TCS Positioned as a Leader in Worldwide Discrete Manufacturing Product Lifecycle Management Strategic Consulting Services and Systems Integration by IDC MarketScape
      View all
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      11 Jun 2025 TCS and PTC Present the North America Leadership Forum 2025
      04 Jun 2025 Veeva R&D and Quality Summit: Developing Better Health Outcomes
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    TCS’ cutting-edge genomics research services

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    Life Sciences This will open an overlay

    Patient-centered Care Models Taking Center Stage in Life Sciences

    Read how patient-centric care models and pharma innovation are ushering new trends in life sciences to improve patient outcomes and enrich lives.
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     about Patient-centered Care Models Taking Center Stage in Life Sciences
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    Veeva R&D and Quality Summit: Developing Better Health Outcomes
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    TCS Pharmacovigilance Services: Ensuring Regulatory Compliance
    Learn how our PV consultants provide late case monitoring, regulatory compliance monitoring, CAPA management, and other services for increased efficiencies.
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    White Paper
    15 May 2025

    Highlights

    • Accelerate genomic interpretation with TCS’ Genomics Research Services
    • Discover new cures, personalize therapies
    • Get access to a state-of-the-art genomics laboratory
    • Leverage a combination of open source and proprietary algorithms

    In this article

    Applying multi-omics inpage
    Overview inpage
    What we offer inpage
    How you benefit inpage
    The TCS advantage inpage
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    Applying multi-omics Overview What we offer How you benefit The TCS advantage

    Applying multi-omics technology to personalize therapies

    With the shift towards precision medicine, the focus of life sciences research is to capture, correlate, and connect a patient's molecular level information with diseases and treatments

    Multi-omics, an approach that analyzes a combination of genomic, meta-genomic proteomic, epigenomic, phenomic, and omics data to discover new cures—is fast gaining ground. Life sciences organizations and research institutions are in the process of compiling genomic sequences and detailed molecular information of millions of people, to improve wellness and health outcomes.

    TCS' Genomics Research Services enables life sciences organizations to derive actionable insights by providing sophisticated genome sequencing and analysis services enabled by its proprietary tools, algorithms, and platforms. TCS can help design and execute genomics studies that can lead to improved understanding of underlying biology, identification of new targets, and novel biomarkers which in turn lead to personalized therapies and patient stratification for clinical research or treatment selection.

    Overview

    Accelerating genomic interpretation in drug discovery

    While significant improvements in DNA sequencing technologies help generate vast amounts of genomic data, clinical interpretation of this data, for instance, linking of DNA sequence anomalies or variations to the phenotypes and clinical conditions, is a tremendous challenge. The genome interpretation process, is encumbered by the many steps required to assemble raw sequences, perform quality assurance checks, create DNA annotations by integrating information from a multitude of sources, and prioritize variants relevant to the phenotypes of interest.

    TCS’ focus is to use comprehensive data integration and analytics techniques to accelerate genomic interpretation in drug discovery and clinical research efforts, with services which ensure that genome sequencing experiments meet acceptable quality benchmarks, and data quality can be traced back to individual lab steps. TCS’ bioinformatics pipeline for the automated execution of genome as well as metagenome sequence analysis, includes a combination of open source and proprietary algorithms deployed on its in-house or client software platform.

    What we offer

    TCS uses its methodologies, tools, and platforms to design cutting-edge genomics research services

    TCS' Genomics Research Services include:

    • Strategy and design: Option analysis, study planning, protocol development, and execution methodologies
    • Sequencing services: Nucleic acid extraction, library preparation (including custom library design), and sequencing
    • Genome analysis: High quality reproducible genome data analysis with biologically meaningful interpretation
    • Marker identification: Multivariate, model–based, and data mining approaches for potential biomarker candidates

    TCS’ services support various applications such as target resequencing, transcript profiling, miRNA sequencing, and microbiome profiling (16 S rRNA sequencing), with sample processing from different samples including frozen tissue, blood, saliva, FFPE, stool, and so on.

    How you benefit

    TCS’ infrastructure and solutions assist in designing and conducting comprehensive genomic studies

    • Employ advanced and patented genomics analysis solutions in the areas of text mining, variant or gene prioritization algorithms, and metagenomics analysis algorithms
    • Access to a state-of-the-art genomics laboratory for sequencing and validation
    • Refer to automated and expert-reviewed clinical interpretations of patient and individual genetic variations through proven pipelines
    • Gain the ability to adopt a scalable model for varying research workload requirements

    The TCS advantage

    TCS employs a combination of technologies to design and execute genomics studies and discover new cures

    Working with TCS offers advantages including:

    • Proven research expertise with genomics and meta-genomics research collaboration
    • Strong digital capabilities, specifically in big data, analytics, cloud, data integration, and visualization, to develop context-specific pipelines
    • Large-scale transformation experience and the ability to handle scalability and standardization requirements for genomics research
    Figure 1: Aiding genomics-driven health studies with technology

    An illustration highlighting TCS’s services throughout the genome interpretation process, from the planning phase, which includes understanding the R&D problem as well as bioinformatics strategy and models, to the execution phase, which oversees marker identification, sequencing experiments, genome analysis, and interpretation, and the like.

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    Our studies with TCS are having profound implications in the clinic for the families of diagnosed children and influencing the use of genome analysis methods in research laboratories and clinical practice worldwide. This ground-breaking work is helping to redefine how genetic diseases and traits are diagnosed and analyzed.

    STEVEN BRENNER

    Professor, University of California, Berkeley

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